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 Doctors call physical exercise a "polypill," because it can prevent and treat many of the chronic diseases that are associated with aging. A new study of muscle fibers from mice and humans shows how exercise affects gene expression. The exercise-induced changes “reprogram” the epigenetic expression of the fibers to a more youthful state. The findings could provide leads for the development of drugs to mimic these benefits in people who are unable to exercise. Research shows that people who exercise regularly not only strengthen their muscles but also improve their overall health, regardless of how late in life they start. For example, recent studies have found that exercise reduces the risk of cardiovascular disease, as well as Alzheimer's and Parkinson's in older people. Conversely, reductions in muscle mass and strength are associated with lower quality of life and higher mortality from all causes. As a result of its proven ability to prevent and treat several chro

 The midweek injury reports for the conference championship round of the NFL playoffs Finally, we have established our final four for the 2022 NFL season, and now, it's time to decide which teams will play in Super Bowl LVII. The San Francisco 49ers, Philadelphia Eagles, Cincinnati Bengals and Kansas City Chiefs are entering what is Week 21 of the season, and all four teams are dealing with injuries. Below, we will break down the midweek injury reports for conference championship Sunday. Who's in? Who's out? Who's trending in the right direction? This is your one-stop shop for everything injury related in the NFL.

Apple is using fewer chips in M2 Macs to provide the same amount of storage. In our review of Apple's new M2 MacBook Pros, our testing showed that the laptops' internal storage speeds were higher than those in the M1 MacBook Pros they replaced. But that won't be true for all models—9to5Mac has discovered that for the entry-level models with 512GB of storage, the M2 MacBook Pro's storage is slower than that in the M1 version. The high-level Blackmagic Disk Speed Test shows the 512GB version of the M1 Pro MacBook Pro with a 4,900 MB/s read speed and 3,951 MB/s write speed, while the M2 Pro version shows a 2,973 MB/s read speed and 3,154.5 MB /s write speed. That's a drop of 40 percent for read speeds and 20 percent for write speeds.

Galaxy S21 Ultra to Galaxy S23 Ultra: Reasons to upgrade, a few not to The Galaxy S23 Ultra is just one week away from its official unveiling. All the leaked information so far has painted a positive picture. Samsung upgraded almost every aspect of its upcoming flagship for 2023, and the Galaxy S23 Ultra is an interesting proposition for Samsung flagship customers, especially those living in markets where trade-in values are stellar. We've already listed plenty of reasons why the Galaxy S23 Ultra might be a worthwhile upgrade for Galaxy S20 Ultra customers. But what about Galaxy S21 Ultra users? Should they consider the Galaxy S23 Ultra as their next flagship phone? Let's answer this by looking at all the improvements the 2023 flagship brings over the 2021 model, and the things you might lose by switching to the newer phone.

 පොදු ආකෘති පත්‍ර බාගත කරන්න අධි පහතසන්ධිය භාවිතා කරමින් ආකෘති පත්ර බාගත කරන්න 3 පොදු ආකෘති පත්‍රය - අළුත් ආකෘති පත්‍රයක් මුද්‍රණය කිරීම සඳහා ඉල්ලුම් පත්‍රය ---   5 පොදු ආකෘති පත්‍රය - හදිසි නිවාඩු සඳහා හෙට 1357, 1381, 1386 F.R.R. යටතේ ---   21 පොදු ආකෘති පත්‍රය - නොමිලේ දෙන නිවාඩු දුම්රිය බලපත්‍ර ඉල්ලුම් පත්‍රය ---   29 පොදු ආකෘති පත්‍රය - ආදායමෙන් ආපසු ගෙවීම සඳහා ඉල්ලුම් කරන විට---   පොදු 35 ආකෘති පත්රය ---   පොදු 35 A අතිකාල දීමනා ආරම්භය ---  පොදු 38 D ආකෘති පත්රය ---   පොදු 39 ආකෘති පත්රය ---   පොදු 42 H අක්ෂරය දරණ ගිණුම (මුදල් රෙගුලාසි 353 බලන්න) ---   පොදු 47 ප්‍රයෝජනයට ගත නොහැකි භාණ්ඩ ලේඛන වසර ---   පොදු 53 A විශ්‍රාම වැටුප් හිමි නිලධාරීන් පිළිබඳ චර්යා සටහන් ---  55 විශ්‍රාම වැටුප් ව්‍යවස්ථා සංග්‍රහය යටතේ විශ්‍රාම වැටුප/ පාරිතෝෂිකය/ මරණ පාරිතෝෂිකය/ තුවාල දිනාව/ විශ්‍රාම විශ්‍රාම වැටුප් සඳහා විශ්‍රාම ව්‍යවස්ථා සංග්‍රහය ---  පොදු 70 රික්විෂන්ස්  පොදු 71 මුදල් තැම්පත් කිරිම් පිළිබඳ සංක්ෂිප්ත සටහන --- පොදු 86 වැන්දඹු හා අනදරු විශ්‍රාම වැටුප් ---  පොදු 86 A වැන්දඹු පුරුෂ හා අනත්දරු ව

  My smiley face creations.

 American-made electric sedan coming in 2026 Sony and Honda hope you're feeling their new car company's name. The tech and auto giants created Sony Honda Mobility last year to develop an electric vehicle brand and announced at CES on Wednesday that it will be called Afeela. "Afeela expresses an interactive relationship where people "feel" mobility as an intelligent entity, and mobility "feels" people and society using sensing and network IT technologies," the company said. HONDA LAUNCHING $7,400 VAN Afeela will begin selling cars in 2026. (AP Photo/John Locher) The four-door sedan features simple styling that is equipped with a massive suite of electronics. The Afeela sedan has 45 sensors on it. (Afeela) It includes 45 sensors made by Sony inside and out that include cameras, radar and lidar to enable its safety, semi-autonomous driving and interactive systems. The Afeela's interior has a widescreen digital display and video sideview mirrors. (

Na'vi ruled and cats drooled at the weekend box office with Black Panther: Wakanda Forever holding onto third place         It certainly is a happy new year for James Cameron and his blue brotherhood as Avatar: The Way of Water topped the box office for the third week in a row.           The sequel to the highest grossing movie of all time is doing some pretty decent numbers for itself, pulling in, per Comscore, an estimated $63.4 million over the weekend, taking its domestic cume to $421.5 million. That brings it within $16 million of Black Panther: Wakanda Forever's cume so far of $437.9 million over eight weeks.           Globally, The Way of Water grossed another $186.7 million, for an international cume of $957 million, making it the highest grossing international release of 2022 and the second highest grossing international release since the start of the pandemic. Cameron's blockbuster had already surpassed the worldwide billion dollar mark last week , putting its

  5. Arcade Paradise           I've always been obsessed with the idea of "games within games". It's part of the appeal of series like Shenmue and Yakuza to me; I love the idea of being able to deviate from the core storyline to experience something completely different, before returning to the campaign when I'm ready. I get the sense that the team at Newcastle-based developer Nosebleed Interactive is cut from the same cloth as me, and it elevates that concept to extraordinary levels with its tycoon-based minigame compilation simulation Arcade Paradise. 4. Train Sim World 3           I liked Train Sim World 3 a lot to begin with, and then they added the Birmingham Cross-City Line as an expansion. Having grown up traveling on a Class 323, with its iconic sci-fi style acceleration sounds, seeing some of my local stations replicated meticulously on a PS5 proved a real uncanny moment. Outside of that, though, I think Dovetail is really beginning to get better at craft